There are many reasons why store.exe would use lots of memory. The strangest one i have found recently was failed backups.
After performing a backup of the mailbox databases the memory utilisation of store.exe dropped from 15.6Gb to 2.9Gb.
The drop in the above screen capture was 1 of 3 drops that occurred during the backup process. So if your store.exe is using heaps of memory and you cannot explain it. Check when your last backup was successful.
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